![]() ![]() Pulmonary arterial hypertension (PAH) is a condition characterized by progressive narrowing of the small pulmonary arteries that if left untreated leads to right heart failure and death. Pulmonary artery and PAW oxyhemoglobin tracked with disease severity and survival in PAH. ![]() The pulmonary gradient of methemoglobin was lower in PAH patients compared to controls and a higher PAW blood methemoglobin was associated with a more pronounced pulmonary vascular response to inhaled nitric oxide. Marked differences were observed in the gasometric determinations between PAW and PA blood. In group 1 PAH (age 58 ± 15 years, 72% females), methemoglobin in the PAW was lower than in the PA blood (0.83% ± 0.43 vs 0.95% ± 0.50, p = 0.03) and was directly associated with the degree of change in pulmonary vascular resistance ( R = 0.35, p = 0.02) during inhaled nitric oxide test. In all groups, PAW blood had higher pH, carboxyhemoglobin and lactate as well as lower pCO 2 than PA blood. We included a total of 130 patients, 65 had group 1 PAH, 40 had pulmonary hypertension (PH) from groups 2–5 and 25 had no PH during RHC. Methodsĭuring right heart catheterization (RHC) we obtained blood from pulmonary artery (PA) and pulmonary artery wedge (PAW) positions and used co-oximetry to test their gasometric differences. We sought to determine these gradients in group 1 PAH and assess their association with disease severity and survival. Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). ![]()
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